Talk: 17 July 2018 at 10:30 in PZ 901
Dragan Bosnacki, Eindhoven University of Technology, The Netherlands: Analysis of a Boolean Model for Rheumatoid Arthritis Using SMT Solvers
Software and Systems Engineering Invited Presentation:
Tuesday, 17.7.2018, 10:30, PZ 901
Dragan Bosnacki
http://www.win.tue.nl/~dragan/
Title: Analysis of a Boolean Model for Rheumatoid Arthritis Using SMT Solvers
Abstract:
Rheumatoid Arthritis (RA) is an autoimmune disease that affects about one percent of the world population. A medicine for RA has not yet been found, current treatment options only decelerating the progress of the disease. In this work a Boolean network model for RA is analyzed. Two kinds of models, synchronous and asynchronous are compared. Attractors in the state space of the models are identified that correspond to the steady states and stable cycles of the network. To this end Satisfiability Modulo Theory (SMT) solvers and an adaptation of the Tarjan’s algorithm for finding strongly connected components in a graph are used for the synchronous and asynchronous models, respectively. By analyzing the stability of the network nodes potential drug targets are identified. The results show a significant overlap with similar findings in the literature which indicates that the Boolean networks can be a feasible approach for identifying biomarkers and drug targets.